:root {
  --bg: #f7f7f5; --paper: #ffffff; --text: #1d1f23; --muted: #5d636e; --line: #e3e4e8;
  --accent: #2557a7; --accent-bg: #e8eefb; --risk: #b42318; --risk-bg: #fdecea;
  --ok: #1e7a46; --ok-bg: #e7f5ec; --warn: #8a6100; --warn-bg: #fff4dc;
  --bar: #2557a7; --shadow: 0 1px 2px rgba(0,0,0,.06), 0 2px 8px rgba(0,0,0,.04);
}
@media (prefers-color-scheme: dark) {
  :root {
    --bg: #121417; --paper: #1b1e22; --text: #e8e9eb; --muted: #9aa1ab; --line: #2c3036;
    --accent: #7aa7ff; --accent-bg: #1d2a44; --risk: #ff8a80; --risk-bg: #3a1d1b;
    --ok: #6fd39a; --ok-bg: #17301f; --warn: #f2c46b; --warn-bg: #33290f; --bar: #7aa7ff;
    --shadow: none;
  }
}
* { box-sizing: border-box; }
body { margin: 0; background: var(--bg); color: var(--text);
  font: 16px/1.55 system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; }
a { color: var(--accent); text-decoration: none; }
a:hover { text-decoration: underline; }
.header { display: flex; justify-content: space-between; align-items: center; padding: 14px 24px;
  border-bottom: 1px solid var(--line); background: var(--paper); }
.brand { font-weight: 700; font-size: 20px; color: var(--text); letter-spacing: -.01em; }
.header nav { display: flex; gap: 18px; align-items: center; }
.langs { display: inline-flex; }
.lang-button { border: 1px solid var(--line); background: transparent; color: var(--muted);
  padding: 3px 8px; cursor: pointer; font: inherit; font-size: 13px; margin-left: -1px; }
.lang-button:first-child { border-radius: 6px 0 0 6px; margin-left: 0; }
.lang-button:last-child { border-radius: 0 6px 6px 0; }
.lang-button[aria-pressed="true"] { color: var(--text); background: var(--accent-bg); font-weight: 600; }
.disclaimer { background: var(--warn-bg); color: var(--text); padding: 10px 24px; font-size: 14px;
  border-bottom: 1px solid var(--line); }
main { max-width: 1240px; margin: 0 auto; padding: 24px 16px 60px; }
.search h1 { font-size: 28px; line-height: 1.25; margin: 18px 0 6px; letter-spacing: -.01em; }
.subtitle { color: var(--muted); margin: 0 0 18px; }
.search-box { position: relative; }
#q { width: 100%; font: inherit; font-size: 18px; padding: 12px 14px; border: 1px solid var(--line);
  border-radius: 10px; background: var(--paper); color: var(--text); box-shadow: var(--shadow); }
#q:focus { outline: 2px solid var(--accent); outline-offset: 1px; }
#suggestions { list-style: none; margin: 4px 0 0; padding: 4px; position: absolute; left: 0; right: 0;
  background: var(--paper); border: 1px solid var(--line); border-radius: 10px; box-shadow: var(--shadow);
  z-index: 5; max-height: 360px; overflow: auto; display: none; }
#suggestions li { padding: 8px 10px; border-radius: 6px; cursor: pointer; display: flex; justify-content: space-between; gap: 12px; }
#suggestions li[aria-selected="true"], #suggestions li:hover { background: var(--accent-bg); }
#suggestions .no-data { color: var(--muted); font-size: 13px; white-space: nowrap; }
.examples { color: var(--muted); font-size: 14px; }
.search.compact h1, .search.compact .subtitle, .search.compact .examples { display: none; }

.disease-page h2 { font-size: 26px; margin: 26px 0 4px; }
.meta { color: var(--muted); font-size: 14px; margin-bottom: 14px; }
.card { background: var(--paper); border: 1px solid var(--line); border-radius: 12px; padding: 18px 20px;
  margin: 18px 0; box-shadow: var(--shadow); }
.card h3 { margin: 0 0 4px; font-size: 18px; }
.card .help { color: var(--muted); font-size: 14px; margin: 0 0 12px; }
.known dl { display: grid; grid-template-columns: 170px 1fr; gap: 6px 14px; margin: 0; font-size: 15px; }
.known dt { color: var(--muted); }
.known dd { margin: 0; }
.tag { font-size: 12.5px; padding: 2px 8px; border-radius: 999px; white-space: nowrap; }
.tag.risk { background: var(--risk-bg); color: var(--risk); }
.tag.ok { background: var(--ok-bg); color: var(--ok); }
.tag.warn { background: var(--warn-bg); color: var(--warn); }
.tag.neutral { background: var(--line); color: var(--muted); }
.chip { display: inline-block; font-size: 12px; line-height: 1.4; padding: 1px 7px; margin: 1px 0; border-radius: 4px;
  white-space: nowrap; border: 1px solid transparent; cursor: default; }
.chip.ev { background: var(--accent-bg); color: var(--accent); border-color: var(--accent-bg); font-weight: 600; }
.chip.ev2 { background: transparent; color: var(--accent); border-color: var(--accent-bg); }
.chip.risk { background: var(--risk-bg); color: var(--risk); }
.chip.contra { background: var(--risk); color: #fff; }
.chip.neutral { background: var(--line); color: var(--muted); }
.chip.info { background: var(--warn-bg); color: var(--warn); }
.gen { font-family: ui-monospace, "SFMono-Regular", Consolas, monospace; font-size: 13px; white-space: nowrap; }
.gen sup { font-family: system-ui, sans-serif; color: var(--muted); margin-left: 1px; }
.genes summary { cursor: pointer; color: var(--muted); font-size: 14px; }
.genes p { margin: 6px 0 0; line-height: 1.9; }
.genes .gen { background: var(--paper); border: 1px solid var(--line); border-radius: 4px; padding: 1px 5px; }
.tools { display: flex; justify-content: flex-end; margin: -4px 0 8px; }
.button { border: 1px solid var(--line); background: var(--paper); color: var(--text); border-radius: 6px;
  padding: 4px 10px; cursor: pointer; font: inherit; font-size: 13px; }
.button:hover { border-color: var(--accent); color: var(--accent); }
.table-scroll { overflow-x: auto; -webkit-overflow-scrolling: touch; margin: 0 -4px; }
.table { border-collapse: collapse; width: 100%; font-size: 14px; }
.table th { text-align: left; font-weight: 600; font-size: 12.5px; text-transform: uppercase; letter-spacing: .03em;
  color: var(--muted); border-bottom: 2px solid var(--line); padding: 6px 8px; white-space: nowrap; }
.table td { border-bottom: 1px solid var(--line); padding: 8px; vertical-align: top; }
.table td.n { color: var(--muted); font-variant-numeric: tabular-nums; text-align: right; width: 1%; }
.table tr.row { cursor: pointer; }
.table tr.row:hover td, .table tr.row[aria-expanded="true"] td { background: var(--accent-bg); }
.table tr.row:focus { outline: 2px solid var(--accent); outline-offset: -2px; }
.table td.toggle { color: var(--muted); width: 1%; }
.table tr.detail-row td { background: var(--bg); }
.drug-name { font-weight: 600; font-size: 15px; }
.small { font-size: 13px; }
.pval { color: var(--muted); font-size: 12.5px; white-space: nowrap; }
.detail { font-size: 14px; padding: 2px 4px 6px; max-width: 900px; }
.detail h4 { margin: 10px 0 2px; font-size: 12.5px; text-transform: uppercase; letter-spacing: .03em; color: var(--muted); }
.detail ul { margin: 2px 0; padding-left: 18px; }
.detail li { margin: 2px 0; }
.detail p { margin: 6px 0; }
.links { font-size: 13px; color: var(--muted); }
.links a { margin-right: 12px; white-space: nowrap; }
.table.targets td.links a { display: block; margin: 0 0 2px; }
details.exploratory summary { cursor: pointer; list-style: revert; }
details.exploratory summary h3 { display: inline; }
.warning { color: var(--risk); }
.muted { color: var(--muted); font-size: 14.5px; }
.prose { max-width: 760px; }
.prose table { border-collapse: collapse; width: 100%; font-size: 14.5px; margin: 10px 0 18px; }
.prose th, .prose td { border-bottom: 1px solid var(--line); padding: 6px 8px; text-align: left; }
.prose td.n { text-align: right; font-variant-numeric: tabular-nums; }
.footer { text-align: center; color: var(--muted); font-size: 13px; padding: 20px 16px 30px; }
.loading { color: var(--muted); padding: 30px 0; font-size: 15px; }
.loading .step { margin: 4px 0; }
.loading .step.done { color: var(--muted); opacity: .75; }
.loading .step.current { color: var(--text); }
.loading .dots::after { content: ""; display: inline-block; width: 1.5em; text-align: left; animation: dots 1.2s steps(4, end) infinite; }
@keyframes dots { 0% { content: ""; } 25% { content: "."; } 50% { content: ".."; } 75% { content: "..."; } }
@media (prefers-reduced-motion: reduce) { .loading .dots::after { animation: none; content: "…"; } }
@media (max-width: 640px) {
  .header { padding: 12px 16px; }
  .disclaimer { padding: 10px 16px; }
  .known dl { grid-template-columns: 1fr; }
  .table { font-size: 13px; min-width: 860px; }
  .table.targets { min-width: 760px; }
  .table td, .table th { padding: 6px 5px; }
}
.detail .feedback { margin-top: 8px; padding-top: 6px; border-top: 1px dashed var(--line); }